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Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir

BACKGROUND: Several studies have suggested an association between poor oral health and esophageal squamous cell carcinoma (ESCC). We conducted a case-control study in Kashmir, a region with relatively high incidence of ESCC in north India, to investigate the association between oral hygiene and ESCC...

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Autores principales: Dar, N A, Islami, F, Bhat, G A, Shah, I A, Makhdoomi, M A, Iqbal, B, Rafiq, R, Lone, M M, Abnet, C C, Boffetta, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778293/
https://www.ncbi.nlm.nih.gov/pubmed/23900216
http://dx.doi.org/10.1038/bjc.2013.437
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author Dar, N A
Islami, F
Bhat, G A
Shah, I A
Makhdoomi, M A
Iqbal, B
Rafiq, R
Lone, M M
Abnet, C C
Boffetta, P
author_facet Dar, N A
Islami, F
Bhat, G A
Shah, I A
Makhdoomi, M A
Iqbal, B
Rafiq, R
Lone, M M
Abnet, C C
Boffetta, P
author_sort Dar, N A
collection PubMed
description BACKGROUND: Several studies have suggested an association between poor oral health and esophageal squamous cell carcinoma (ESCC). We conducted a case-control study in Kashmir, a region with relatively high incidence of ESCC in north India, to investigate the association between oral hygiene and ESCC risk. METHODS: We recruited 703 histologically confirmed ESCC cases, and 1664 controls individually matched to the cases for age, sex, and district of residence. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We found an inverse association between teeth cleaning and ESCC risk. As compared with never cleaning teeth, the OR (95% CI) was 0.41 (0.28–0.62) for cleaning less than daily and 0.44 (0.25–0.77) for cleaning at least once a day (P for trend=0.026) in models adjusted for multiple potential confounders, including several indicators of socioeconomic status. This association persisted after we limited our analyses to never tobacco users. The inverse association between cleaning teeth and ESCC was stronger with using brushes than with using sticks/fingers. We also found an association between the number of decayed, filled, and missing teeth and ESCC risk, but the trend of the associations was not statistically significant. Avoiding solid food and cold beverages because of teeth and oral problems were also associated with ESCC risk. CONCLUSION: We found an association between poor oral hygiene indicators and ESCC risk, supporting the previous studies that showed the same associations.
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spelling pubmed-37782932014-09-03 Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir Dar, N A Islami, F Bhat, G A Shah, I A Makhdoomi, M A Iqbal, B Rafiq, R Lone, M M Abnet, C C Boffetta, P Br J Cancer Epidemiology BACKGROUND: Several studies have suggested an association between poor oral health and esophageal squamous cell carcinoma (ESCC). We conducted a case-control study in Kashmir, a region with relatively high incidence of ESCC in north India, to investigate the association between oral hygiene and ESCC risk. METHODS: We recruited 703 histologically confirmed ESCC cases, and 1664 controls individually matched to the cases for age, sex, and district of residence. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: We found an inverse association between teeth cleaning and ESCC risk. As compared with never cleaning teeth, the OR (95% CI) was 0.41 (0.28–0.62) for cleaning less than daily and 0.44 (0.25–0.77) for cleaning at least once a day (P for trend=0.026) in models adjusted for multiple potential confounders, including several indicators of socioeconomic status. This association persisted after we limited our analyses to never tobacco users. The inverse association between cleaning teeth and ESCC was stronger with using brushes than with using sticks/fingers. We also found an association between the number of decayed, filled, and missing teeth and ESCC risk, but the trend of the associations was not statistically significant. Avoiding solid food and cold beverages because of teeth and oral problems were also associated with ESCC risk. CONCLUSION: We found an association between poor oral hygiene indicators and ESCC risk, supporting the previous studies that showed the same associations. Nature Publishing Group 2013-09-03 2013-07-30 /pmc/articles/PMC3778293/ /pubmed/23900216 http://dx.doi.org/10.1038/bjc.2013.437 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Dar, N A
Islami, F
Bhat, G A
Shah, I A
Makhdoomi, M A
Iqbal, B
Rafiq, R
Lone, M M
Abnet, C C
Boffetta, P
Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title_full Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title_fullStr Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title_full_unstemmed Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title_short Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir
title_sort poor oral hygiene and risk of esophageal squamous cell carcinoma in kashmir
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778293/
https://www.ncbi.nlm.nih.gov/pubmed/23900216
http://dx.doi.org/10.1038/bjc.2013.437
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