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The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow
The application of a monolithic form of triphenylphosphine to the Ramirez gem-dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem-dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purificatio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778394/ https://www.ncbi.nlm.nih.gov/pubmed/24062843 http://dx.doi.org/10.3762/bjoc.9.207 |
| _version_ | 1782285106040274944 |
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| author | Roper, Kimberley A Berry, Malcolm B Ley, Steven V |
| author_facet | Roper, Kimberley A Berry, Malcolm B Ley, Steven V |
| author_sort | Roper, Kimberley A |
| collection | PubMed |
| description | The application of a monolithic form of triphenylphosphine to the Ramirez gem-dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem-dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purification. It is also possible to perform the Appel reaction using the same monolith and the relationship between the mechanisms of the two reactions is discussed. |
| format | Online Article Text |
| id | pubmed-3778394 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37783942013-09-23 The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow Roper, Kimberley A Berry, Malcolm B Ley, Steven V Beilstein J Org Chem Full Research Paper The application of a monolithic form of triphenylphosphine to the Ramirez gem-dibromoolefination reaction using flow chemistry techniques is reported. A variety of gem-dibromides were synthesised in high purity and excellent yield following only removal of solvent and no further off-line purification. It is also possible to perform the Appel reaction using the same monolith and the relationship between the mechanisms of the two reactions is discussed. Beilstein-Institut 2013-09-02 /pmc/articles/PMC3778394/ /pubmed/24062843 http://dx.doi.org/10.3762/bjoc.9.207 Text en Copyright © 2013, Roper et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Full Research Paper Roper, Kimberley A Berry, Malcolm B Ley, Steven V The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title | The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title_full | The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title_fullStr | The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title_full_unstemmed | The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title_short | The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow |
| title_sort | application of a monolithic triphenylphosphine reagent for conducting ramirez gem-dibromoolefination reactions in flow |
| topic | Full Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778394/ https://www.ncbi.nlm.nih.gov/pubmed/24062843 http://dx.doi.org/10.3762/bjoc.9.207 |
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