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Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functi...

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Detalles Bibliográficos
Autores principales: Hammachi, Fella, Morrison, Gillian M., Sharov, Alexei A., Livigni, Alessandra, Narayan, Santosh, Papapetrou, Eirini P., O'Malley, James, Kaji, Keisuke, Ko, Minoru S.H., Ptashne, Mark, Brickman, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778438/
https://www.ncbi.nlm.nih.gov/pubmed/22832160
http://dx.doi.org/10.1016/j.celrep.2011.12.002