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Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency
Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functi...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778438/ https://www.ncbi.nlm.nih.gov/pubmed/22832160 http://dx.doi.org/10.1016/j.celrep.2011.12.002 |