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The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain

The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the ER (endoplasmic reticulum) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and inactivate ribosomes. The currently accepted mod...

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Detalles Bibliográficos
Autores principales:	Pietroni, Paola, Vasisht, Nishi, Cook, Jonathan P., Roberts, David M., Lord, J. Michael, Hartmann-Petersen, Rasmus, Roberts, Lynne M., Spooner, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778710/ https://www.ncbi.nlm.nih.gov/pubmed/23617410 http://dx.doi.org/10.1042/BJ20130133

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