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Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy

Imatinib mesylate (IM), an anticancer drug, has been widely used to treat chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and dermato-fibrosarcoma protuberans. Cutaneous reactions to IM have been reported to occur in varying number of patients in different case series. Non-li...

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Autor principal: Ghosh, Sudip Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778782/
https://www.ncbi.nlm.nih.gov/pubmed/24082187
http://dx.doi.org/10.4103/0019-5154.117315
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author Ghosh, Sudip Kumar
author_facet Ghosh, Sudip Kumar
author_sort Ghosh, Sudip Kumar
collection PubMed
description Imatinib mesylate (IM), an anticancer drug, has been widely used to treat chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and dermato-fibrosarcoma protuberans. Cutaneous reactions to IM have been reported to occur in varying number of patients in different case series. Non-lichenoid cutaneous reactions secondary to IM have been well-documented in the literature and are the commonest non-hematologic adverse reactions associated with its use. Lichenoid drug eruption (LDE) associated with IM therapy has rarely been reported in the literature. A case of a generalized LDE associated with IM therapy has been described here for its rarity and interesting clinical presentation. As the clinical usage of IM is increasing, one might expect an increasing number of similar patients in the future. It is thus important to realize the potential of IM to produce LDE and to differentiate this entity from idiopathic lichen planus. In the present article, the reports of IM-associated LDE, described in the PubMed and Medline database (in English language literature), have also been reviewed.
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spelling pubmed-37787822013-09-30 Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy Ghosh, Sudip Kumar Indian J Dermatol Case Report Imatinib mesylate (IM), an anticancer drug, has been widely used to treat chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and dermato-fibrosarcoma protuberans. Cutaneous reactions to IM have been reported to occur in varying number of patients in different case series. Non-lichenoid cutaneous reactions secondary to IM have been well-documented in the literature and are the commonest non-hematologic adverse reactions associated with its use. Lichenoid drug eruption (LDE) associated with IM therapy has rarely been reported in the literature. A case of a generalized LDE associated with IM therapy has been described here for its rarity and interesting clinical presentation. As the clinical usage of IM is increasing, one might expect an increasing number of similar patients in the future. It is thus important to realize the potential of IM to produce LDE and to differentiate this entity from idiopathic lichen planus. In the present article, the reports of IM-associated LDE, described in the PubMed and Medline database (in English language literature), have also been reviewed. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3778782/ /pubmed/24082187 http://dx.doi.org/10.4103/0019-5154.117315 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ghosh, Sudip Kumar
Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title_full Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title_fullStr Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title_full_unstemmed Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title_short Generalized Lichenoid Drug Eruption Associated with Imatinib Mesylate Therapy
title_sort generalized lichenoid drug eruption associated with imatinib mesylate therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778782/
https://www.ncbi.nlm.nih.gov/pubmed/24082187
http://dx.doi.org/10.4103/0019-5154.117315
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