Multiple Familial Trichoepithelioma with Malignant Transformation

Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Ma...

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Detalles Bibliográficos
Autores principales: Samaka, Rehab M, Bakry, Ola A, Seleit, Iman, Abdelwahed, Moshira M, Hassan, Rania A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
E-Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778810/
https://www.ncbi.nlm.nih.gov/pubmed/24082215
http://dx.doi.org/10.4103/0019-5154.117348
Descripción
Sumario:Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Malignant transformation is very rare. We present a case of MFT in a female patient and her father with malignant transformation to basal cell carcinoma (BCC) in the father. We summarized the main histological differential parameters between TE and BCC and applied immunophenotyping for both by administration of Bcl2, CD34, CD10 and androgen receptor (AR) antibodies.

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