Multiple Familial Trichoepithelioma with Malignant Transformation

Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Ma...

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Autores principales: Samaka, Rehab M, Bakry, Ola A, Seleit, Iman, Abdelwahed, Moshira M, Hassan, Rania A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
E-Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778810/
https://www.ncbi.nlm.nih.gov/pubmed/24082215
http://dx.doi.org/10.4103/0019-5154.117348
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author Samaka, Rehab M
Bakry, Ola A
Seleit, Iman
Abdelwahed, Moshira M
Hassan, Rania A
author_facet Samaka, Rehab M
Bakry, Ola A
Seleit, Iman
Abdelwahed, Moshira M
Hassan, Rania A
author_sort Samaka, Rehab M
collection PubMed
description Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Malignant transformation is very rare. We present a case of MFT in a female patient and her father with malignant transformation to basal cell carcinoma (BCC) in the father. We summarized the main histological differential parameters between TE and BCC and applied immunophenotyping for both by administration of Bcl2, CD34, CD10 and androgen receptor (AR) antibodies.
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spelling pubmed-37788102013-09-30 Multiple Familial Trichoepithelioma with Malignant Transformation Samaka, Rehab M Bakry, Ola A Seleit, Iman Abdelwahed, Moshira M Hassan, Rania A Indian J Dermatol E-Case Report Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Malignant transformation is very rare. We present a case of MFT in a female patient and her father with malignant transformation to basal cell carcinoma (BCC) in the father. We summarized the main histological differential parameters between TE and BCC and applied immunophenotyping for both by administration of Bcl2, CD34, CD10 and androgen receptor (AR) antibodies. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3778810/ /pubmed/24082215 http://dx.doi.org/10.4103/0019-5154.117348 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle E-Case Report
Samaka, Rehab M
Bakry, Ola A
Seleit, Iman
Abdelwahed, Moshira M
Hassan, Rania A
Multiple Familial Trichoepithelioma with Malignant Transformation
title Multiple Familial Trichoepithelioma with Malignant Transformation
title_full Multiple Familial Trichoepithelioma with Malignant Transformation
title_fullStr Multiple Familial Trichoepithelioma with Malignant Transformation
title_full_unstemmed Multiple Familial Trichoepithelioma with Malignant Transformation
title_short Multiple Familial Trichoepithelioma with Malignant Transformation
title_sort multiple familial trichoepithelioma with malignant transformation
topic E-Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778810/
https://www.ncbi.nlm.nih.gov/pubmed/24082215
http://dx.doi.org/10.4103/0019-5154.117348
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