Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs

Mammalian HELQ is a 3′–5′ DNA helicase with strand displacement activity. Here we show that HELQ participates in a pathway of resistance to DNA interstrand crosslinks (ICLs). Genetic disruption of HELQ in human cells enhances cellular sensitivity and chromosome radial formation by the ICL-inducing a...

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Detalles Bibliográficos
Autores principales: Takata, Kei-ichi, Reh, Shelley, Tomida, Junya, Person, Maria D., Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778836/
https://www.ncbi.nlm.nih.gov/pubmed/24005565
http://dx.doi.org/10.1038/ncomms3338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778836/
https://www.ncbi.nlm.nih.gov/pubmed/24005565
http://dx.doi.org/10.1038/ncomms3338

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