Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes

Identifying loci with parental differences in DNA methylation is key to unraveling parent-of-origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free postimplantation mouse embryos (Dnmt3L-/+), we demonstrate that maternal-specific methylation exists very scarcely at midgesta...

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Detalles Bibliográficos
Autores principales: Proudhon, Charlotte, Duffié, Rachel, Ajjan, Sophie, Cowley, Michael, Iranzo, Julian, Carbajosa, Guillermo, Saadeh, Heba, Holland, Michelle L., Oakey, Rebecca J., Rakyan, Vardhman K., Schulz, Reiner, Bourc’his, Déborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778900/
https://www.ncbi.nlm.nih.gov/pubmed/22902559
http://dx.doi.org/10.1016/j.molcel.2012.07.010

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