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Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the hydrolysis of the phosphodiester linkage between the DNA 3′ phosphate and a tyrosine residue as well as a variety of other DNA 3′ damaged termini. Recently we have shown that Tdp1 can liberate the 3′ DNA phosphate termini from apurinic/apyrimidini...

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Detalles Bibliográficos
Autores principales:	Lebedeva, Natalia A., Rechkunova, Nadejda I., El-Khamisy, Sherif F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editions Scientifiques Elsevier 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778944/ https://www.ncbi.nlm.nih.gov/pubmed/22522093 http://dx.doi.org/10.1016/j.biochi.2012.04.004

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