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Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism

Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing i...

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Autores principales: Dufour, Nicholas, Redcay, Elizabeth, Young, Liane, Mavros, Penelope L., Moran, Joseph M., Triantafyllou, Christina, Gabrieli, John D. E., Saxe, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779167/
https://www.ncbi.nlm.nih.gov/pubmed/24073267
http://dx.doi.org/10.1371/journal.pone.0075468
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author Dufour, Nicholas
Redcay, Elizabeth
Young, Liane
Mavros, Penelope L.
Moran, Joseph M.
Triantafyllou, Christina
Gabrieli, John D. E.
Saxe, Rebecca
author_facet Dufour, Nicholas
Redcay, Elizabeth
Young, Liane
Mavros, Penelope L.
Moran, Joseph M.
Triantafyllou, Christina
Gabrieli, John D. E.
Saxe, Rebecca
author_sort Dufour, Nicholas
collection PubMed
description Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults.
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spelling pubmed-37791672013-09-26 Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism Dufour, Nicholas Redcay, Elizabeth Young, Liane Mavros, Penelope L. Moran, Joseph M. Triantafyllou, Christina Gabrieli, John D. E. Saxe, Rebecca PLoS One Research Article Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults. Public Library of Science 2013-09-20 /pmc/articles/PMC3779167/ /pubmed/24073267 http://dx.doi.org/10.1371/journal.pone.0075468 Text en © 2013 Dufour et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dufour, Nicholas
Redcay, Elizabeth
Young, Liane
Mavros, Penelope L.
Moran, Joseph M.
Triantafyllou, Christina
Gabrieli, John D. E.
Saxe, Rebecca
Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title_full Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title_fullStr Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title_full_unstemmed Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title_short Similar Brain Activation during False Belief Tasks in a Large Sample of Adults with and without Autism
title_sort similar brain activation during false belief tasks in a large sample of adults with and without autism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779167/
https://www.ncbi.nlm.nih.gov/pubmed/24073267
http://dx.doi.org/10.1371/journal.pone.0075468
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