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Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

Matrix metalloproteinases (MMPs) play central roles in vertebrate tissue development, remodeling, and repair. The endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, bi...

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Detalles Bibliográficos
Autores principales:	Batra, Jyotica, Soares, Alexei S., Mehner, Christine, Radisky, Evette S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779175/ https://www.ncbi.nlm.nih.gov/pubmed/24073280 http://dx.doi.org/10.1371/journal.pone.0075836

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