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Novel CD47: SIRPα Dependent Mechanism for the Activation of STAT3 in Antigen-Presenting Cell
Cell surface CD47 interacts with its receptor, signal-regulatory-protein α (SIRPα) that is expressed predominantly on macrophages, to inhibit phagocytosis of normal, healthy cells. This “don’t eat me” signal is mediated through tyrosine phosphorylation of SIRPα at the cytoplasmic ITIM motifs and the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779186/ https://www.ncbi.nlm.nih.gov/pubmed/24073274 http://dx.doi.org/10.1371/journal.pone.0075595 |