Cargando…
Of inflammasomes and pathogens – sensing of microbes by the inflammasome
Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2. Upon formation, inflammasomes...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779445/ https://www.ncbi.nlm.nih.gov/pubmed/23666718 http://dx.doi.org/10.1002/emmm.201201771 |
_version_ | 1782285249500151808 |
---|---|
author | Bauernfeind, Franz Hornung, Veit |
author_facet | Bauernfeind, Franz Hornung, Veit |
author_sort | Bauernfeind, Franz |
collection | PubMed |
description | Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2. Upon formation, inflammasomes trigger proteolysis of caspase-1, which subsequently leads to a potent inflammatory response through the maturation and secretion of IL-1 family cytokines, which can be accompanied by an inflammatory cell death termed pyroptosis. Here, we review the sensing mechanisms of the currently characterized inflammasome complexes and discuss how they are involved in the innate immune response against microbial pathogens. We especially highlight recent advances in the molecular understanding of how microbial patterns are detected and discriminated from endogenous compounds by inflammasome sensors. Further, we review how inflammasomes contribute to the anti microbial host defense by cytokine-dependent and cell autonomous mechanisms. |
format | Online Article Text |
id | pubmed-3779445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | WILEY-VCH Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-37794452013-09-23 Of inflammasomes and pathogens – sensing of microbes by the inflammasome Bauernfeind, Franz Hornung, Veit EMBO Mol Med Reviews Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2. Upon formation, inflammasomes trigger proteolysis of caspase-1, which subsequently leads to a potent inflammatory response through the maturation and secretion of IL-1 family cytokines, which can be accompanied by an inflammatory cell death termed pyroptosis. Here, we review the sensing mechanisms of the currently characterized inflammasome complexes and discuss how they are involved in the innate immune response against microbial pathogens. We especially highlight recent advances in the molecular understanding of how microbial patterns are detected and discriminated from endogenous compounds by inflammasome sensors. Further, we review how inflammasomes contribute to the anti microbial host defense by cytokine-dependent and cell autonomous mechanisms. WILEY-VCH Verlag 2013-06 2013-05-13 /pmc/articles/PMC3779445/ /pubmed/23666718 http://dx.doi.org/10.1002/emmm.201201771 Text en Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Reviews Bauernfeind, Franz Hornung, Veit Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title | Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title_full | Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title_fullStr | Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title_full_unstemmed | Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title_short | Of inflammasomes and pathogens – sensing of microbes by the inflammasome |
title_sort | of inflammasomes and pathogens – sensing of microbes by the inflammasome |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779445/ https://www.ncbi.nlm.nih.gov/pubmed/23666718 http://dx.doi.org/10.1002/emmm.201201771 |
work_keys_str_mv | AT bauernfeindfranz ofinflammasomesandpathogenssensingofmicrobesbytheinflammasome AT hornungveit ofinflammasomesandpathogenssensingofmicrobesbytheinflammasome |