Cargando…

A TSPO ligand is protective in a mouse model of multiple sclerosis

Local production of neurosteroids such as progesterone and allopregnanolone confers neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial translocator protein (TSPO) performs a rate-limiting step in the conversion of cholesterol to pregnenolone and its steroid deri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daugherty, Daniel J, Selvaraj, Vimal, Chechneva, Olga V, Liu, Xiao-Bo, Pleasure, David E, Deng, Wenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779450/ https://www.ncbi.nlm.nih.gov/pubmed/23681668 http://dx.doi.org/10.1002/emmm.201202124

Ejemplares similares

The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis
por: Daugherty, Daniel J., et al.
Publicado: (2016)

Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation
por: Chechneva, Olga V., et al.
Publicado: (2016)

Crucial Role Reported for TSPO in Viability and Steroidogenesis is a Misconception. Commentary: Conditional Steroidogenic Cell-Targeted Deletion of TSPO Unveils a Crucial Role in Viability and Hormone-Dependent Steroid Formation
por: Selvaraj, Vimal, et al.
Publicado: (2016)

Imaging neuroinflammation in multiple sclerosis using TSPO-PET
por: Airas, Laura, et al.
Publicado: (2015)

hESC-derived Olig2(+) progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
por: Jiang, Peng, et al.
Publicado: (2013)

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury
por: Chechneva, O V, et al.
Publicado: (2014)

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
por: Kang, Yeona, et al.
Publicado: (2021)

Commentary: Amhr2-Cre-Mediated Global Tspo Knockout
por: Selvaraj, Vimal, et al.
Publicado: (2020)

Empowering sonic hedgehog to rescue brain cells after ischemic stroke
por: Chechneva, Olga V., et al.
Publicado: (2015)

TSPO imaging using the novel PET ligand [(18)F]GE-180: quantification approaches in patients with multiple sclerosis
por: Vomacka, Lena, et al.
Publicado: (2017)

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO
por: Iatmanen-Harbi, Soria, et al.
Publicado: (2019)

The New Dipeptide TSPO Ligands: Design, Synthesis and Structure–Anxiolytic Activity Relationship †
por: Gudasheva, Tatiana A., et al.
Publicado: (2020)

TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis
por: Polvinen, Eero, et al.
Publicado: (2023)

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands
por: Veenman, Leo, et al.
Publicado: (2016)

Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
por: Shehadeh, Mona, et al.
Publicado: (2019)

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
por: Lejri, Imane, et al.
Publicado: (2019)

Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting
por: Wang, Yan, et al.
Publicado: (2021)

TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation
por: Ma, Baoyu, et al.
Publicado: (2022)

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis
por: Xiao, Juan, et al.
Publicado: (2015)

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis
por: Sucksdorff, Marcus, et al.
Publicado: (2020)

The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia
por: Liu, Xiao-Bo, et al.
Publicado: (2016)

Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling
por: Yasin, Nasra, et al.
Publicado: (2017)

Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
por: Soundarapandian, Mangala M., et al.
Publicado: (2011)

A TSPO ligand attenuates brain injury after intracerebral hemorrhage
por: Li, Minshu, et al.
Publicado: (2017)

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis
por: Takahashi, Kazuya, et al.
Publicado: (2007)

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being
por: Da Pozzo, Eleonora, et al.
Publicado: (2016)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination
por: Sokias, Renee, et al.
Publicado: (2016)

The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy
por: Lan, Nannan, et al.
Publicado: (2021)

Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
por: Guo, Qi, et al.
Publicado: (2012)

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
por: Grimm, Amandine, et al.
Publicado: (2019)

Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain
por: Mayrhofer, Florian, et al.
Publicado: (2023)

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [(18)F]FEDAA1106
por: Takano, Akihiro, et al.
Publicado: (2013)

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels
por: Lopalco, Antonio, et al.
Publicado: (2018)

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain
por: Nutma, Erik, et al.
Publicado: (2021)

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?
por: Roncaroli, Federico, et al.
Publicado: (2016)

Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina
por: Farhan, Fahad, et al.
Publicado: (2021)

TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
por: Costa, Barbara, et al.
Publicado: (2016)

Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study
por: Buck, Jason R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p8t06oko7t36qv7gejlgrp0qhj