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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

The combinations of genetic alterations that cooperate with von Hippel–Lindau (VHL) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly understood. We show that the TP53 tumour suppressor gene is mutated in approximately 9% of human ccRCCs. Combined deletion of Vhl and Trp53 in p...

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Detalles Bibliográficos
Autores principales:	Albers, Joachim, Rajski, Michal, Schönenberger, Désirée, Harlander, Sabine, Schraml, Peter, von Teichman, Adriana, Georgiev, Strahil, Wild, Peter J, Moch, Holger, Krek, Wilhelm, Frew, Ian J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779454/ https://www.ncbi.nlm.nih.gov/pubmed/23606570 http://dx.doi.org/10.1002/emmm.201202231

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