Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement()

A subset of patients with relapsing-remitting multiple sclerosis (RRMS) on therapy with interferon beta (IFNβ) develop neutralising anti-drug antibodies (ADA) resulting in reduced, or loss of, therapeutic efficacy. The aims were to characterise the relative contributions of anti-IFNβ antibody isotyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Sethu, Swaminathan, Govindappa, Karthik, Quinn, Paul, Wadhwa, Meenu, Stebbings, Richard, Boggild, Mike, Naisbitt, Dean, Kimber, Ian, Pirmohamed, Munir, Park, Kevin, Sathish, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779799/
https://www.ncbi.nlm.nih.gov/pubmed/23770627
http://dx.doi.org/10.1016/j.clim.2013.05.008

Ejemplares similares

Ejemplares similares