Metabolic modulation of chromatin: implications for DNA repair and genomic integrity

The maintenance of genomic integrity in response to DNA damage is tightly linked to controlled changes in the damage-proximal chromatin environment. Many of the chromatin modifying enzymes involved in DNA repair depend on metabolic intermediates as cofactors, suggesting that changes in cellular meta...

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Detalles Bibliográficos
Autores principales: Liu, Jinping, Kim, Jeongkyu, Oberdoerffer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779809/
https://www.ncbi.nlm.nih.gov/pubmed/24065984
http://dx.doi.org/10.3389/fgene.2013.00182
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author Liu, Jinping
Kim, Jeongkyu
Oberdoerffer, Philipp
author_facet Liu, Jinping
Kim, Jeongkyu
Oberdoerffer, Philipp
author_sort Liu, Jinping
collection PubMed
description The maintenance of genomic integrity in response to DNA damage is tightly linked to controlled changes in the damage-proximal chromatin environment. Many of the chromatin modifying enzymes involved in DNA repair depend on metabolic intermediates as cofactors, suggesting that changes in cellular metabolism can have direct consequences for repair efficiency and ultimately, genome stability. Here, we discuss how metabolites may contribute to DNA double-strand break repair, and how alterations in cellular metabolism associated with both aging and tumorigenesis may affect the integrity of our genomes.
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spelling pubmed-37798092013-09-24 Metabolic modulation of chromatin: implications for DNA repair and genomic integrity Liu, Jinping Kim, Jeongkyu Oberdoerffer, Philipp Front Genet Genetics The maintenance of genomic integrity in response to DNA damage is tightly linked to controlled changes in the damage-proximal chromatin environment. Many of the chromatin modifying enzymes involved in DNA repair depend on metabolic intermediates as cofactors, suggesting that changes in cellular metabolism can have direct consequences for repair efficiency and ultimately, genome stability. Here, we discuss how metabolites may contribute to DNA double-strand break repair, and how alterations in cellular metabolism associated with both aging and tumorigenesis may affect the integrity of our genomes. Frontiers Media S.A. 2013-09-17 /pmc/articles/PMC3779809/ /pubmed/24065984 http://dx.doi.org/10.3389/fgene.2013.00182 Text en Copyright © Liu, Kim and Oberdoerffer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Liu, Jinping
Kim, Jeongkyu
Oberdoerffer, Philipp
Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title_full Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title_fullStr Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title_full_unstemmed Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title_short Metabolic modulation of chromatin: implications for DNA repair and genomic integrity
title_sort metabolic modulation of chromatin: implications for dna repair and genomic integrity
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779809/
https://www.ncbi.nlm.nih.gov/pubmed/24065984
http://dx.doi.org/10.3389/fgene.2013.00182
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AT kimjeongkyu metabolicmodulationofchromatinimplicationsfordnarepairandgenomicintegrity
AT oberdoerfferphilipp metabolicmodulationofchromatinimplicationsfordnarepairandgenomicintegrity

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