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Cortical β-amyloid levels and neurocognitive performance after cardiac surgery
INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to several years after surgery. More importantly,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780320/ https://www.ncbi.nlm.nih.gov/pubmed/24056491 http://dx.doi.org/10.1136/bmjopen-2013-003669 |
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author | Klinger, Rebecca Y James, Olga G Wong, Terence Z Newman, Mark F Doraiswamy, P Murali Mathew, Joseph P |
author_facet | Klinger, Rebecca Y James, Olga G Wong, Terence Z Newman, Mark F Doraiswamy, P Murali Mathew, Joseph P |
author_sort | Klinger, Rebecca Y |
collection | PubMed |
description | INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to several years after surgery. More importantly, perioperative cognitive decline is predictive of long-term cognitive dysfunction, reduced quality of life and increased mortality. The proposed mechanisms to explain the cognitive decline associated with cardiac surgery include the neurotoxic accumulation of β-amyloid. This study will be the first to provide molecular imaging to assess the relationship between neocortical β-amyloid deposition and postoperative cognitive dysfunction. METHODS AND ANALYSIS: 40 patients providing informed consent for participation in this Institutional Review Board-approved study and undergoing cardiac (coronary artery bypass graft (CABG), valve or CABG+valve) surgery with cardiopulmonary bypass will be enrolled based on defined inclusion and exclusion criteria. At 6 weeks after surgery, participants will undergo (18)F-florbetapir positron emission tomography imaging to assess neocortical β-amyloid burden along with a standard neurocognitive battery and blood testing for apolipoprotein E ε-4 genotype. RESULTS: The results will be compared to those of 40 elderly controls and 40 elderly patients with mild cognitive impairment who have previously completed (18)F-florbetapir imaging. ETHICS AND DISSEMINATION: This study has been approved by the Duke University Institutional Review Board. The results will provide novel mechanistic insights into postoperative cognitive dysfunction that will inform future studies into potential treatments or preventative therapies of long-term cognitive decline after cardiac surgery. |
format | Online Article Text |
id | pubmed-3780320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37803202013-09-30 Cortical β-amyloid levels and neurocognitive performance after cardiac surgery Klinger, Rebecca Y James, Olga G Wong, Terence Z Newman, Mark F Doraiswamy, P Murali Mathew, Joseph P BMJ Open Anaesthesia INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to several years after surgery. More importantly, perioperative cognitive decline is predictive of long-term cognitive dysfunction, reduced quality of life and increased mortality. The proposed mechanisms to explain the cognitive decline associated with cardiac surgery include the neurotoxic accumulation of β-amyloid. This study will be the first to provide molecular imaging to assess the relationship between neocortical β-amyloid deposition and postoperative cognitive dysfunction. METHODS AND ANALYSIS: 40 patients providing informed consent for participation in this Institutional Review Board-approved study and undergoing cardiac (coronary artery bypass graft (CABG), valve or CABG+valve) surgery with cardiopulmonary bypass will be enrolled based on defined inclusion and exclusion criteria. At 6 weeks after surgery, participants will undergo (18)F-florbetapir positron emission tomography imaging to assess neocortical β-amyloid burden along with a standard neurocognitive battery and blood testing for apolipoprotein E ε-4 genotype. RESULTS: The results will be compared to those of 40 elderly controls and 40 elderly patients with mild cognitive impairment who have previously completed (18)F-florbetapir imaging. ETHICS AND DISSEMINATION: This study has been approved by the Duke University Institutional Review Board. The results will provide novel mechanistic insights into postoperative cognitive dysfunction that will inform future studies into potential treatments or preventative therapies of long-term cognitive decline after cardiac surgery. BMJ Publishing Group 2013-09-20 /pmc/articles/PMC3780320/ /pubmed/24056491 http://dx.doi.org/10.1136/bmjopen-2013-003669 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Anaesthesia Klinger, Rebecca Y James, Olga G Wong, Terence Z Newman, Mark F Doraiswamy, P Murali Mathew, Joseph P Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title | Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title_full | Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title_fullStr | Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title_full_unstemmed | Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title_short | Cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
title_sort | cortical β-amyloid levels and neurocognitive performance after cardiac surgery |
topic | Anaesthesia |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780320/ https://www.ncbi.nlm.nih.gov/pubmed/24056491 http://dx.doi.org/10.1136/bmjopen-2013-003669 |
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