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In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study

OBJECTIVE: To investigate whether in utero exposure to antidepressants is associated with increased risk of attention deficit hyperactivity disorder (ADHD). DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: All Danish singletons born alive from 1996 to 2009 were included. Using national medical...

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Autores principales: Laugesen, Kristina, Olsen, Morten Smærup, Telén Andersen, Ane Birgitte, Frøslev, Trine, Toft Sørensen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780335/
https://www.ncbi.nlm.nih.gov/pubmed/24056487
http://dx.doi.org/10.1136/bmjopen-2013-003507
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author Laugesen, Kristina
Olsen, Morten Smærup
Telén Andersen, Ane Birgitte
Frøslev, Trine
Toft Sørensen, Henrik
author_facet Laugesen, Kristina
Olsen, Morten Smærup
Telén Andersen, Ane Birgitte
Frøslev, Trine
Toft Sørensen, Henrik
author_sort Laugesen, Kristina
collection PubMed
description OBJECTIVE: To investigate whether in utero exposure to antidepressants is associated with increased risk of attention deficit hyperactivity disorder (ADHD). DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: All Danish singletons born alive from 1996 to 2009 were included. Using national medical registries, we defined in utero exposure to antidepressants as redemption of an antidepressant prescription by the mother 30 days prior to or during pregnancy. We defined maternal former users of antidepressants as women, who had redeemed a prescription up to 30 days prior to pregnancy, and never users as women who had never redeemed a prescription. MAIN OUTCOME MEASURES: ADHD was defined as redemption of a prescription for ADHD medication or an ADHD hospital diagnosis. Children were followed through 2010, and we used proportional-hazards regression to compute adjusted HRs comparing children exposed in utero and children born to former antidepressant users with children born to never users. To adjust for confounding from family-related factors, we conducted a within-mother between-pregnancy analysis comparing exposed children with unexposed siblings using conditional logistic regression. RESULTS: We identified a cohort of 877 778 children, of whom 1.7% were exposed in utero. The overall median follow-up time was 8 years; selective serotonin reuptake inhibitors were the most commonly used class of antidepressant during pregnancy (78% of users). The adjusted HR comparing children exposed to any antidepressant in utero with children born to never users was 1.2 (95% CI 1.1 to 1.4), and 1.6 (95% CI 1.5 to 1.8) comparing children born to former users to children born to never users of antidepressants. In the within-mother between-pregnancy analysis (n=867), the adjusted OR was 0.7 (95% CI 0.4 to 1.4). CONCLUSIONS: This study provides no evidence to support a causal association between in utero exposure to antidepressants and risk of ADHD.
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spelling pubmed-37803352013-09-30 In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study Laugesen, Kristina Olsen, Morten Smærup Telén Andersen, Ane Birgitte Frøslev, Trine Toft Sørensen, Henrik BMJ Open Epidemiology OBJECTIVE: To investigate whether in utero exposure to antidepressants is associated with increased risk of attention deficit hyperactivity disorder (ADHD). DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: All Danish singletons born alive from 1996 to 2009 were included. Using national medical registries, we defined in utero exposure to antidepressants as redemption of an antidepressant prescription by the mother 30 days prior to or during pregnancy. We defined maternal former users of antidepressants as women, who had redeemed a prescription up to 30 days prior to pregnancy, and never users as women who had never redeemed a prescription. MAIN OUTCOME MEASURES: ADHD was defined as redemption of a prescription for ADHD medication or an ADHD hospital diagnosis. Children were followed through 2010, and we used proportional-hazards regression to compute adjusted HRs comparing children exposed in utero and children born to former antidepressant users with children born to never users. To adjust for confounding from family-related factors, we conducted a within-mother between-pregnancy analysis comparing exposed children with unexposed siblings using conditional logistic regression. RESULTS: We identified a cohort of 877 778 children, of whom 1.7% were exposed in utero. The overall median follow-up time was 8 years; selective serotonin reuptake inhibitors were the most commonly used class of antidepressant during pregnancy (78% of users). The adjusted HR comparing children exposed to any antidepressant in utero with children born to never users was 1.2 (95% CI 1.1 to 1.4), and 1.6 (95% CI 1.5 to 1.8) comparing children born to former users to children born to never users of antidepressants. In the within-mother between-pregnancy analysis (n=867), the adjusted OR was 0.7 (95% CI 0.4 to 1.4). CONCLUSIONS: This study provides no evidence to support a causal association between in utero exposure to antidepressants and risk of ADHD. BMJ Publishing Group 2013-09-20 /pmc/articles/PMC3780335/ /pubmed/24056487 http://dx.doi.org/10.1136/bmjopen-2013-003507 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Epidemiology
Laugesen, Kristina
Olsen, Morten Smærup
Telén Andersen, Ane Birgitte
Frøslev, Trine
Toft Sørensen, Henrik
In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title_full In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title_fullStr In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title_full_unstemmed In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title_short In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study
title_sort in utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide danish cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780335/
https://www.ncbi.nlm.nih.gov/pubmed/24056487
http://dx.doi.org/10.1136/bmjopen-2013-003507
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