Cargando…
Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936
Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Psychological Association
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780714/ https://www.ncbi.nlm.nih.gov/pubmed/23937481 http://dx.doi.org/10.1037/a0033354 |
_version_ | 1782285332786446336 |
---|---|
author | Booth, Tom Bastin, Mark E. Penke, Lars Maniega, Susana Muñoz Murray, Catherine Royle, Natalie A. Gow, Alan J. Corley, Janie Henderson, Ross D. Valdés Hernández, Maria del C. Starr, John M. Wardlaw, Joanna M. Deary, Ian J. |
author_facet | Booth, Tom Bastin, Mark E. Penke, Lars Maniega, Susana Muñoz Murray, Catherine Royle, Natalie A. Gow, Alan J. Corley, Janie Henderson, Ross D. Valdés Hernández, Maria del C. Starr, John M. Wardlaw, Joanna M. Deary, Ian J. |
author_sort | Booth, Tom |
collection | PubMed |
description | Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables. |
format | Online Article Text |
id | pubmed-3780714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Psychological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-37807142013-10-01 Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 Booth, Tom Bastin, Mark E. Penke, Lars Maniega, Susana Muñoz Murray, Catherine Royle, Natalie A. Gow, Alan J. Corley, Janie Henderson, Ross D. Valdés Hernández, Maria del C. Starr, John M. Wardlaw, Joanna M. Deary, Ian J. Neuropsychology Articles Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables. American Psychological Association 2013-08-12 2013-09 /pmc/articles/PMC3780714/ /pubmed/23937481 http://dx.doi.org/10.1037/a0033354 Text en © 2013 the Authors http://creativecommons.org/licenses/by/3.0/ This article has been published under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher. |
spellingShingle | Articles Booth, Tom Bastin, Mark E. Penke, Lars Maniega, Susana Muñoz Murray, Catherine Royle, Natalie A. Gow, Alan J. Corley, Janie Henderson, Ross D. Valdés Hernández, Maria del C. Starr, John M. Wardlaw, Joanna M. Deary, Ian J. Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title_full | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title_fullStr | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title_full_unstemmed | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title_short | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
title_sort | brain white matter tract integrity and cognitive abilities in community-dwelling older people: the lothian birth cohort, 1936 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780714/ https://www.ncbi.nlm.nih.gov/pubmed/23937481 http://dx.doi.org/10.1037/a0033354 |
work_keys_str_mv | AT boothtom brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT bastinmarke brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT penkelars brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT maniegasusanamunoz brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT murraycatherine brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT roylenataliea brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT gowalanj brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT corleyjanie brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT hendersonrossd brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT valdeshernandezmariadelc brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT starrjohnm brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT wardlawjoannam brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 AT dearyianj brainwhitemattertractintegrityandcognitiveabilitiesincommunitydwellingolderpeoplethelothianbirthcohort1936 |