A Small-Animal Pharmacokinetic/Pharmacodynamic PET Study of Central Serotonin 1A Receptor Occupancy by a Potential Therapeutic Agent for Overactive Bladder

Serotonin 1A (5-HT(1A)) receptors have been mechanistically implicated in micturition control, and there has been a need for an appropriate biomarker surrogating the potency of a provisional drug acting on this receptor system for developing a new therapeutic approach to overactive bladder (OAB). He...

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Detalles Bibliográficos
Autores principales: Nakatani, Yosuke, Suzuki, Michiyuki, Tokunaga, Masaki, Maeda, Jun, Sakai, Miyuki, Ishihara, Hiroki, Yoshinaga, Takashi, Takenaka, Osamu, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781034/
https://www.ncbi.nlm.nih.gov/pubmed/24086433
http://dx.doi.org/10.1371/journal.pone.0075040

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