High-Level Expression, Purification and Characterization of a Constitutively Active Thromboxane A2 Receptor Polymorphic Variant

G protein-coupled receptors (GPCRs) exhibit some level of basal signaling even in the absence of a bound agonist. This basal or constitutive signaling can have important pathophysiological roles. In the past few years, a number of high resolution crystal structures of GPCRs have been reported, inclu...

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Detalles Bibliográficos
Autores principales: Xu, Bing, Chakraborty, Raja, Eilers, Markus, Dakshinamurti, Shyamala, O’Neil, Joe D., Smith, Steven O., Bhullar, Rajinder P., Chelikani, Prashen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781061/
https://www.ncbi.nlm.nih.gov/pubmed/24086743
http://dx.doi.org/10.1371/journal.pone.0076481

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