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Cytochrome P450 CYP1B1 Interacts with 8-Methoxypsoralen (8-MOP) and Influences Psoralen-Ultraviolet A (PUVA) Sensitivity

BACKGROUND: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis. Psoralens are metabolised by cytochrome P450 enzymes (P450), and we hypothesised that variability in cutaneous P450 expression ma...

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Detalles Bibliográficos
Autores principales:	Deeni, Yusuf Y., Ibbotson, Sally H., Woods, Julie A., Wolf, C. Roland, Smith, Gillian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781062/ https://www.ncbi.nlm.nih.gov/pubmed/24086543 http://dx.doi.org/10.1371/journal.pone.0075494

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