Improvement of Neuromuscular Synaptic Phenotypes without Enhanced Survival and Motor Function in Severe Spinal Muscular Atrophy Mice Selectively Rescued in Motor Neurons

In the inherited childhood neuromuscular disease spinal muscular atrophy (SMA), lower motor neuron death and severe muscle weakness result from the reduction of the ubiquitously expressed protein survival of motor neuron (SMN). Although SMA mice recapitulate many features of the human disease, it ha...

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Detalles Bibliográficos
Autores principales: Paez-Colasante, Ximena, Seaberg, Bonnie, Martinez, Tara L., Kong, Lingling, Sumner, Charlotte J., Rimer, Mendell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781079/
https://www.ncbi.nlm.nih.gov/pubmed/24086650
http://dx.doi.org/10.1371/journal.pone.0075866

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