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Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation
One factor which may be important for determining proper lesion creation during atrial ablation is catheter-endocardial contact. Little information is available that relates geometric contact, depth and angle, to ablation lesion formation. We present an electrothermal computer model of ablation that...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781109/ https://www.ncbi.nlm.nih.gov/pubmed/24086275 http://dx.doi.org/10.1371/journal.pone.0073242 |
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author | Gallagher, Neal Fear, Elise C. Byrd, Israel A. Vigmond, Edward J. |
author_facet | Gallagher, Neal Fear, Elise C. Byrd, Israel A. Vigmond, Edward J. |
author_sort | Gallagher, Neal |
collection | PubMed |
description | One factor which may be important for determining proper lesion creation during atrial ablation is catheter-endocardial contact. Little information is available that relates geometric contact, depth and angle, to ablation lesion formation. We present an electrothermal computer model of ablation that calculated lesion volume and temperature development over time. The Pennes bioheat equation was coupled to a quasistatic electrical problem to investigate the effect of catheter penetration depth, as well as incident catheter angle as may occur in practice. Biological experiments were performed to verify the modelling of electrical phenomena. Results show that for deeply penetrating tips, acute catheter angles reduced the rate of temperature buildup, allowing larger lesions to form before temperatures elevated excessively. It was also found that greater penetration did not lead to greater transmurality of lesions. We conclude that catheter contact angle plays a significant role in lesion formation, and the time course must be considered. This is clinically relevant because proper identification and prediction of geometric contact variables could improve ablation efficacy. |
format | Online Article Text |
id | pubmed-3781109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37811092013-10-01 Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation Gallagher, Neal Fear, Elise C. Byrd, Israel A. Vigmond, Edward J. PLoS One Research Article One factor which may be important for determining proper lesion creation during atrial ablation is catheter-endocardial contact. Little information is available that relates geometric contact, depth and angle, to ablation lesion formation. We present an electrothermal computer model of ablation that calculated lesion volume and temperature development over time. The Pennes bioheat equation was coupled to a quasistatic electrical problem to investigate the effect of catheter penetration depth, as well as incident catheter angle as may occur in practice. Biological experiments were performed to verify the modelling of electrical phenomena. Results show that for deeply penetrating tips, acute catheter angles reduced the rate of temperature buildup, allowing larger lesions to form before temperatures elevated excessively. It was also found that greater penetration did not lead to greater transmurality of lesions. We conclude that catheter contact angle plays a significant role in lesion formation, and the time course must be considered. This is clinically relevant because proper identification and prediction of geometric contact variables could improve ablation efficacy. Public Library of Science 2013-09-23 /pmc/articles/PMC3781109/ /pubmed/24086275 http://dx.doi.org/10.1371/journal.pone.0073242 Text en © 2013 Gallagher et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gallagher, Neal Fear, Elise C. Byrd, Israel A. Vigmond, Edward J. Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title | Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title_full | Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title_fullStr | Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title_full_unstemmed | Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title_short | Contact Geometry Affects Lesion Formation in Radio-Frequency Cardiac Catheter Ablation |
title_sort | contact geometry affects lesion formation in radio-frequency cardiac catheter ablation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781109/ https://www.ncbi.nlm.nih.gov/pubmed/24086275 http://dx.doi.org/10.1371/journal.pone.0073242 |
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