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High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreov...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781132/ https://www.ncbi.nlm.nih.gov/pubmed/24086385 http://dx.doi.org/10.1371/journal.pone.0074855 |
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author | Lambotte, Olivier Pollara, Justin Boufassa, Faroudy Moog, Christiane Venet, Alain Haynes, Barton F. Delfraissy, Jean-François Saez-Cirion, Asier Ferrari, Guido |
author_facet | Lambotte, Olivier Pollara, Justin Boufassa, Faroudy Moog, Christiane Venet, Alain Haynes, Barton F. Delfraissy, Jean-François Saez-Cirion, Asier Ferrari, Guido |
author_sort | Lambotte, Olivier |
collection | PubMed |
description | The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers. |
format | Online Article Text |
id | pubmed-3781132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37811322013-10-01 High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers Lambotte, Olivier Pollara, Justin Boufassa, Faroudy Moog, Christiane Venet, Alain Haynes, Barton F. Delfraissy, Jean-François Saez-Cirion, Asier Ferrari, Guido PLoS One Research Article The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers. Public Library of Science 2013-09-23 /pmc/articles/PMC3781132/ /pubmed/24086385 http://dx.doi.org/10.1371/journal.pone.0074855 Text en © 2013 Lambotte et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lambotte, Olivier Pollara, Justin Boufassa, Faroudy Moog, Christiane Venet, Alain Haynes, Barton F. Delfraissy, Jean-François Saez-Cirion, Asier Ferrari, Guido High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title | High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title_full | High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title_fullStr | High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title_full_unstemmed | High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title_short | High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers |
title_sort | high antibody-dependent cellular cytotoxicity responses are correlated with strong cd8 t cell viral suppressive activity but not with b57 status in hiv-1 elite controllers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781132/ https://www.ncbi.nlm.nih.gov/pubmed/24086385 http://dx.doi.org/10.1371/journal.pone.0074855 |
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