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High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreov...

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Autores principales: Lambotte, Olivier, Pollara, Justin, Boufassa, Faroudy, Moog, Christiane, Venet, Alain, Haynes, Barton F., Delfraissy, Jean-François, Saez-Cirion, Asier, Ferrari, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781132/
https://www.ncbi.nlm.nih.gov/pubmed/24086385
http://dx.doi.org/10.1371/journal.pone.0074855
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author Lambotte, Olivier
Pollara, Justin
Boufassa, Faroudy
Moog, Christiane
Venet, Alain
Haynes, Barton F.
Delfraissy, Jean-François
Saez-Cirion, Asier
Ferrari, Guido
author_facet Lambotte, Olivier
Pollara, Justin
Boufassa, Faroudy
Moog, Christiane
Venet, Alain
Haynes, Barton F.
Delfraissy, Jean-François
Saez-Cirion, Asier
Ferrari, Guido
author_sort Lambotte, Olivier
collection PubMed
description The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
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spelling pubmed-37811322013-10-01 High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers Lambotte, Olivier Pollara, Justin Boufassa, Faroudy Moog, Christiane Venet, Alain Haynes, Barton F. Delfraissy, Jean-François Saez-Cirion, Asier Ferrari, Guido PLoS One Research Article The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers. Public Library of Science 2013-09-23 /pmc/articles/PMC3781132/ /pubmed/24086385 http://dx.doi.org/10.1371/journal.pone.0074855 Text en © 2013 Lambotte et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lambotte, Olivier
Pollara, Justin
Boufassa, Faroudy
Moog, Christiane
Venet, Alain
Haynes, Barton F.
Delfraissy, Jean-François
Saez-Cirion, Asier
Ferrari, Guido
High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title_full High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title_fullStr High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title_full_unstemmed High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title_short High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
title_sort high antibody-dependent cellular cytotoxicity responses are correlated with strong cd8 t cell viral suppressive activity but not with b57 status in hiv-1 elite controllers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781132/
https://www.ncbi.nlm.nih.gov/pubmed/24086385
http://dx.doi.org/10.1371/journal.pone.0074855
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