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Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors

MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delive...

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Autor principal: Manoury, Bénédicte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781364/
https://www.ncbi.nlm.nih.gov/pubmed/24065969
http://dx.doi.org/10.3389/fimmu.2013.00299
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author Manoury, Bénédicte
author_facet Manoury, Bénédicte
author_sort Manoury, Bénédicte
collection PubMed
description MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delivered by toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular TLRs in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing.
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spelling pubmed-37813642013-09-24 Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors Manoury, Bénédicte Front Immunol Immunology MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delivered by toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular TLRs in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing. Frontiers Media S.A. 2013-09-24 /pmc/articles/PMC3781364/ /pubmed/24065969 http://dx.doi.org/10.3389/fimmu.2013.00299 Text en Copyright © 2013 Manoury. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Manoury, Bénédicte
Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title_full Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title_fullStr Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title_full_unstemmed Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title_short Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
title_sort proteases: essential actors in processing antigens and intracellular toll-like receptors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781364/
https://www.ncbi.nlm.nih.gov/pubmed/24065969
http://dx.doi.org/10.3389/fimmu.2013.00299
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