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Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors
MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delive...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781364/ https://www.ncbi.nlm.nih.gov/pubmed/24065969 http://dx.doi.org/10.3389/fimmu.2013.00299 |
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author | Manoury, Bénédicte |
author_facet | Manoury, Bénédicte |
author_sort | Manoury, Bénédicte |
collection | PubMed |
description | MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delivered by toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular TLRs in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing. |
format | Online Article Text |
id | pubmed-3781364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37813642013-09-24 Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors Manoury, Bénédicte Front Immunol Immunology MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4(+) T cells. However, to elicit CD4(+)-T cells immunity, pAPCs need an additional signal, which can be delivered by toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular TLRs in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing. Frontiers Media S.A. 2013-09-24 /pmc/articles/PMC3781364/ /pubmed/24065969 http://dx.doi.org/10.3389/fimmu.2013.00299 Text en Copyright © 2013 Manoury. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Manoury, Bénédicte Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title | Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title_full | Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title_fullStr | Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title_full_unstemmed | Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title_short | Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors |
title_sort | proteases: essential actors in processing antigens and intracellular toll-like receptors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781364/ https://www.ncbi.nlm.nih.gov/pubmed/24065969 http://dx.doi.org/10.3389/fimmu.2013.00299 |
work_keys_str_mv | AT manourybenedicte proteasesessentialactorsinprocessingantigensandintracellulartolllikereceptors |