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Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses...

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Autores principales: Hasek, Barbara E., Boudreau, Anik, Shin, Jeho, Feng, Daorong, Hulver, Matthew, Van, Nancy T., Laque, Amanda, Stewart, Laura K., Stone, Kirsten P., Wanders, Desiree, Ghosh, Sujoy, Pessin, Jeffrey E., Gettys, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781441/
https://www.ncbi.nlm.nih.gov/pubmed/23801581
http://dx.doi.org/10.2337/db13-0501
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author Hasek, Barbara E.
Boudreau, Anik
Shin, Jeho
Feng, Daorong
Hulver, Matthew
Van, Nancy T.
Laque, Amanda
Stewart, Laura K.
Stone, Kirsten P.
Wanders, Desiree
Ghosh, Sujoy
Pessin, Jeffrey E.
Gettys, Thomas W.
author_facet Hasek, Barbara E.
Boudreau, Anik
Shin, Jeho
Feng, Daorong
Hulver, Matthew
Van, Nancy T.
Laque, Amanda
Stewart, Laura K.
Stone, Kirsten P.
Wanders, Desiree
Ghosh, Sujoy
Pessin, Jeffrey E.
Gettys, Thomas W.
author_sort Hasek, Barbara E.
collection PubMed
description Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of lipogenic genes in the liver, resulting in a corresponding reduction in the capacity of the liver to synthesize and export lipid. In contrast, the transcriptional response in white adipose tissue (WAT) involved a depot-specific induction of lipogenic and oxidative genes and a commensurate increase in capacity to synthesize and oxidize fatty acids. These responses were accompanied by a significant change in adipocyte morphology, with the MR diet reducing cell size and increasing mitochondrial density across all depots. The coordinated transcriptional remodeling of lipid metabolism between liver and WAT by dietary MR produced an overall reduction in circulating and tissue lipids and provides a potential mechanism for the increase in metabolic flexibility and enhanced insulin sensitivity produced by the diet.
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spelling pubmed-37814412014-10-01 Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats Hasek, Barbara E. Boudreau, Anik Shin, Jeho Feng, Daorong Hulver, Matthew Van, Nancy T. Laque, Amanda Stewart, Laura K. Stone, Kirsten P. Wanders, Desiree Ghosh, Sujoy Pessin, Jeffrey E. Gettys, Thomas W. Diabetes Original Research Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of lipogenic genes in the liver, resulting in a corresponding reduction in the capacity of the liver to synthesize and export lipid. In contrast, the transcriptional response in white adipose tissue (WAT) involved a depot-specific induction of lipogenic and oxidative genes and a commensurate increase in capacity to synthesize and oxidize fatty acids. These responses were accompanied by a significant change in adipocyte morphology, with the MR diet reducing cell size and increasing mitochondrial density across all depots. The coordinated transcriptional remodeling of lipid metabolism between liver and WAT by dietary MR produced an overall reduction in circulating and tissue lipids and provides a potential mechanism for the increase in metabolic flexibility and enhanced insulin sensitivity produced by the diet. American Diabetes Association 2013-10 2013-09-17 /pmc/articles/PMC3781441/ /pubmed/23801581 http://dx.doi.org/10.2337/db13-0501 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Hasek, Barbara E.
Boudreau, Anik
Shin, Jeho
Feng, Daorong
Hulver, Matthew
Van, Nancy T.
Laque, Amanda
Stewart, Laura K.
Stone, Kirsten P.
Wanders, Desiree
Ghosh, Sujoy
Pessin, Jeffrey E.
Gettys, Thomas W.
Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title_full Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title_fullStr Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title_full_unstemmed Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title_short Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
title_sort remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781441/
https://www.ncbi.nlm.nih.gov/pubmed/23801581
http://dx.doi.org/10.2337/db13-0501
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