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Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats

We reported earlier that β-cell–specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic f...

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Detalles Bibliográficos
Autores principales:	Mahadevan, Jana, Parazzoli, Susan, Oseid, Elizabeth, Hertzel, Ann V., Bernlohr, David A., Vallerie, Sara N., Liu, Chang-qin, Lopez, Melissa, Harmon, Jamie S., Robertson, R. Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781455/ https://www.ncbi.nlm.nih.gov/pubmed/23801580 http://dx.doi.org/10.2337/db13-0357

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