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Autologous Pancreatic Islet Transplantation in Human Bone Marrow

The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal. We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety of BM as a site for...

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Autores principales: Maffi, Paola, Balzano, Gianpaolo, Ponzoni, Maurilio, Nano, Rita, Sordi, Valeria, Melzi, Raffaella, Mercalli, Alessia, Scavini, Marina, Esposito, Antonio, Peccatori, Jacopo, Cantarelli, Elisa, Messina, Carlo, Bernardi, Massimo, Del Maschio, Alessandro, Staudacher, Carlo, Doglioni, Claudio, Ciceri, Fabio, Secchi, Antonio, Piemonti, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781459/
https://www.ncbi.nlm.nih.gov/pubmed/23733196
http://dx.doi.org/10.2337/db13-0465
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author Maffi, Paola
Balzano, Gianpaolo
Ponzoni, Maurilio
Nano, Rita
Sordi, Valeria
Melzi, Raffaella
Mercalli, Alessia
Scavini, Marina
Esposito, Antonio
Peccatori, Jacopo
Cantarelli, Elisa
Messina, Carlo
Bernardi, Massimo
Del Maschio, Alessandro
Staudacher, Carlo
Doglioni, Claudio
Ciceri, Fabio
Secchi, Antonio
Piemonti, Lorenzo
author_facet Maffi, Paola
Balzano, Gianpaolo
Ponzoni, Maurilio
Nano, Rita
Sordi, Valeria
Melzi, Raffaella
Mercalli, Alessia
Scavini, Marina
Esposito, Antonio
Peccatori, Jacopo
Cantarelli, Elisa
Messina, Carlo
Bernardi, Massimo
Del Maschio, Alessandro
Staudacher, Carlo
Doglioni, Claudio
Ciceri, Fabio
Secchi, Antonio
Piemonti, Lorenzo
author_sort Maffi, Paola
collection PubMed
description The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal. We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety of BM as a site for islet transplantation in humans. Four patients who developed diabetes after total pancreatectomy were candidates for the autologous transplantation of pancreatic islet. Because the patients had contraindications for intraportal infusion, islets were infused in the BM. In all recipients, islets engrafted successfully as shown by measurable posttransplantation C-peptide levels and histopathological evidence of insulin-producing cells or molecular markers of endocrine tissue in BM biopsy samples analyzed during follow-up. Thus far, we have recorded no adverse events related to the infusion procedure or the presence of islets in the BM. Islet function was sustained for the maximum follow-up of 944 days. The encouraging results of this pilot study provide new perspectives in identifying alternative sites for islet infusion in patients with type 1 diabetes. Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans.
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spelling pubmed-37814592014-10-01 Autologous Pancreatic Islet Transplantation in Human Bone Marrow Maffi, Paola Balzano, Gianpaolo Ponzoni, Maurilio Nano, Rita Sordi, Valeria Melzi, Raffaella Mercalli, Alessia Scavini, Marina Esposito, Antonio Peccatori, Jacopo Cantarelli, Elisa Messina, Carlo Bernardi, Massimo Del Maschio, Alessandro Staudacher, Carlo Doglioni, Claudio Ciceri, Fabio Secchi, Antonio Piemonti, Lorenzo Diabetes Original Research The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal. We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety of BM as a site for islet transplantation in humans. Four patients who developed diabetes after total pancreatectomy were candidates for the autologous transplantation of pancreatic islet. Because the patients had contraindications for intraportal infusion, islets were infused in the BM. In all recipients, islets engrafted successfully as shown by measurable posttransplantation C-peptide levels and histopathological evidence of insulin-producing cells or molecular markers of endocrine tissue in BM biopsy samples analyzed during follow-up. Thus far, we have recorded no adverse events related to the infusion procedure or the presence of islets in the BM. Islet function was sustained for the maximum follow-up of 944 days. The encouraging results of this pilot study provide new perspectives in identifying alternative sites for islet infusion in patients with type 1 diabetes. Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans. American Diabetes Association 2013-10 2013-09-17 /pmc/articles/PMC3781459/ /pubmed/23733196 http://dx.doi.org/10.2337/db13-0465 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Maffi, Paola
Balzano, Gianpaolo
Ponzoni, Maurilio
Nano, Rita
Sordi, Valeria
Melzi, Raffaella
Mercalli, Alessia
Scavini, Marina
Esposito, Antonio
Peccatori, Jacopo
Cantarelli, Elisa
Messina, Carlo
Bernardi, Massimo
Del Maschio, Alessandro
Staudacher, Carlo
Doglioni, Claudio
Ciceri, Fabio
Secchi, Antonio
Piemonti, Lorenzo
Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title_full Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title_fullStr Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title_full_unstemmed Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title_short Autologous Pancreatic Islet Transplantation in Human Bone Marrow
title_sort autologous pancreatic islet transplantation in human bone marrow
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781459/
https://www.ncbi.nlm.nih.gov/pubmed/23733196
http://dx.doi.org/10.2337/db13-0465
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