Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression is decreased in skeletal muscle resulting in increased mitochondrial protein acetylation. Deletion of Sirt3 led to impaired glucose oxidation...

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Detalles Bibliográficos
Autores principales: Jing, Enxuan, O’Neill, Brian T., Rardin, Matthew J., Kleinridders, André, Ilkeyeva, Olga R., Ussar, Siegfried, Bain, James R., Lee, Kevin Y., Verdin, Eric M., Newgard, Christopher B., Gibson, Bradford W., Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781465/
https://www.ncbi.nlm.nih.gov/pubmed/23835326
http://dx.doi.org/10.2337/db12-1650

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