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Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells

The derangement of endoplasmic reticulum (ER) homeostasis triggers β-cell apoptosis, leading to diabetes. Glucokinase upregulates insulin receptor substrate 2 (IRS-2) expression in β-cells, but the role of glucokinase and IRS-2 in ER stress has been unclear. In this study, we investigated the impact...

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Detalles Bibliográficos
Autores principales:	Shirakawa, Jun, Togashi, Yu, Sakamoto, Eri, Kaji, Mitsuyo, Tajima, Kazuki, Orime, Kazuki, Inoue, Hideaki, Kubota, Naoto, Kadowaki, Takashi, Terauchi, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781485/ https://www.ncbi.nlm.nih.gov/pubmed/23801577 http://dx.doi.org/10.2337/db13-0052

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