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Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition
OBJECTIVE: To examine the associations of maternal gestational glucose tolerance with offspring body composition in late childhood. RESEARCH DESIGN AND METHODS: Among 958 women in the prebirth cohort Project Viva, glucose tolerance was assessed in the second trimester by nonfasting 50-g 1-h glucose...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781569/ https://www.ncbi.nlm.nih.gov/pubmed/23877978 http://dx.doi.org/10.2337/dc13-0333 |
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author | Regnault, Nolwenn Gillman, Matthew W. Rifas-Shiman, Sheryl L. Eggleston, Emma Oken, Emily |
author_facet | Regnault, Nolwenn Gillman, Matthew W. Rifas-Shiman, Sheryl L. Eggleston, Emma Oken, Emily |
author_sort | Regnault, Nolwenn |
collection | PubMed |
description | OBJECTIVE: To examine the associations of maternal gestational glucose tolerance with offspring body composition in late childhood. RESEARCH DESIGN AND METHODS: Among 958 women in the prebirth cohort Project Viva, glucose tolerance was assessed in the second trimester by nonfasting 50-g 1-h glucose challenge test (GCT), followed if abnormal by fasting 100-g 3-h oral glucose tolerance test (OGTT). We categorized women as normoglycemic (83.3%) if GCT was ≤140 mg/dL, isolated hyperglycemia (9.1%) if GCT was abnormal but OGTT normal, intermediate glucose intolerance (IGI) (3.3%) if there was one abnormal value on OGTT, or gestational diabetes mellitus (GDM) (4.5%) if there were two or more abnormal OGTT values. Using multivariable linear regression, we examined adjusted associations of glucose tolerance with offspring overall (N = 958) and central (N = 760) adiposity and body composition using dual X-ray absorptiometry (DXA) measured at the school-age visit (95 ± 10 months). RESULTS: Compared with that in the male offspring of normoglycemic mothers, DXA fat mass was higher in male offspring of GDM mothers (1.89 kg [95% CI 0.33–3.45]) but not in male offspring of mothers with IGI (0.06 kg [−1.45 to 1.57]). DXA trunk-to-peripheral fat mass, a measure of central adiposity, was also somewhat higher in male offspring of GDM mothers (0.04 [−0.01 to 0.09]). In girls, DXA fat mass was higher in offspring of mothers with IGI (2.23 kg [0.12–4.34]) but not GDM (−1.25 kg [−3.13 to 0.63]). We showed no association of gestational glucose tolerance with DXA lean mass. CONCLUSIONS: In this study, only male offspring of GDM mothers manifested increased adiposity, whereas only female offspring of mothers with IGI did so. Sex differences in glycemic sensitivity may explain these findings. |
format | Online Article Text |
id | pubmed-3781569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-37815692014-10-01 Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition Regnault, Nolwenn Gillman, Matthew W. Rifas-Shiman, Sheryl L. Eggleston, Emma Oken, Emily Diabetes Care Original Research OBJECTIVE: To examine the associations of maternal gestational glucose tolerance with offspring body composition in late childhood. RESEARCH DESIGN AND METHODS: Among 958 women in the prebirth cohort Project Viva, glucose tolerance was assessed in the second trimester by nonfasting 50-g 1-h glucose challenge test (GCT), followed if abnormal by fasting 100-g 3-h oral glucose tolerance test (OGTT). We categorized women as normoglycemic (83.3%) if GCT was ≤140 mg/dL, isolated hyperglycemia (9.1%) if GCT was abnormal but OGTT normal, intermediate glucose intolerance (IGI) (3.3%) if there was one abnormal value on OGTT, or gestational diabetes mellitus (GDM) (4.5%) if there were two or more abnormal OGTT values. Using multivariable linear regression, we examined adjusted associations of glucose tolerance with offspring overall (N = 958) and central (N = 760) adiposity and body composition using dual X-ray absorptiometry (DXA) measured at the school-age visit (95 ± 10 months). RESULTS: Compared with that in the male offspring of normoglycemic mothers, DXA fat mass was higher in male offspring of GDM mothers (1.89 kg [95% CI 0.33–3.45]) but not in male offspring of mothers with IGI (0.06 kg [−1.45 to 1.57]). DXA trunk-to-peripheral fat mass, a measure of central adiposity, was also somewhat higher in male offspring of GDM mothers (0.04 [−0.01 to 0.09]). In girls, DXA fat mass was higher in offspring of mothers with IGI (2.23 kg [0.12–4.34]) but not GDM (−1.25 kg [−3.13 to 0.63]). We showed no association of gestational glucose tolerance with DXA lean mass. CONCLUSIONS: In this study, only male offspring of GDM mothers manifested increased adiposity, whereas only female offspring of mothers with IGI did so. Sex differences in glycemic sensitivity may explain these findings. American Diabetes Association 2013-10 2013-09-14 /pmc/articles/PMC3781569/ /pubmed/23877978 http://dx.doi.org/10.2337/dc13-0333 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Regnault, Nolwenn Gillman, Matthew W. Rifas-Shiman, Sheryl L. Eggleston, Emma Oken, Emily Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title | Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title_full | Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title_fullStr | Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title_full_unstemmed | Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title_short | Sex-Specific Associations of Gestational Glucose Tolerance With Childhood Body Composition |
title_sort | sex-specific associations of gestational glucose tolerance with childhood body composition |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781569/ https://www.ncbi.nlm.nih.gov/pubmed/23877978 http://dx.doi.org/10.2337/dc13-0333 |
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