Intramesenteric Steroid Treatment for Steroid- Refractory Gastrointestinal Graft Versus Host Disease

Currently, steroid-refractory severe gastrointestinal (GI) graft versus host disease (GVHD) is among the most important complications of allogeneic transplantation, and as yet there is no standard approach to its treatment. Herein we report two cases with steroid-refractory GI GVHD that received int...

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Detalles Bibliográficos
Autores principales: Bilgin, Aynur Uğur, Topcuoğlu, Pervin, Sancak, Tanzer, Konuk, Nahide, Arat, Mutlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781620/
https://www.ncbi.nlm.nih.gov/pubmed/24385731
http://dx.doi.org/10.5505/tjh.2012.57855
Descripción
Sumario:Currently, steroid-refractory severe gastrointestinal (GI) graft versus host disease (GVHD) is among the most important complications of allogeneic transplantation, and as yet there is no standard approach to its treatment. Herein we report two cases with steroid-refractory GI GVHD that received intramesenteric steroid treatment. In both cases the frequency and volume of diarrhea resolved completely following intramesenteric methylprednisolone (MP) injection. In conclusion, intra-arterial steroid injection might be an alternative treatment approach for steroid-refractory GI GVHD. Conflict of interest:None declared.

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