Cargando…

Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4(+) T-cell immunity

The ability to control HCV with IFN-α-based treatments provides an opportunity in humans to study how the rate of viral clearance in vivo impinges on the development of antiviral responses. Ex vivo (IFN-γ-producing) and cultured antiviral CD4(+) T cells, serum cytokines, and viral loads were measure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pembroke, Tom, Rees, Ian, Gallagher, Kathleen, Jones, Emma, Mizen, Paul, Navruzov, Timur, Freedman, Andrew, Fielding, Ceri, Humphreys, Ian R, Wang, Eddie C Y, Gallimore, Awen M, Godkin, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Immunity to Infection
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781703/ https://www.ncbi.nlm.nih.gov/pubmed/22653709 http://dx.doi.org/10.1002/eji.201142072

Ejemplares similares

Avidity of influenza-specific memory CD8(+) T-cell populations decays over time compromising antiviral immunity
por: Humphreys, Ian R, et al.
Publicado: (2012)

CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and-independent mechanisms
por: Longhi, M Paula, et al.
Publicado: (2007)

Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver
por: Pembroke, Tom, et al.
Publicado: (2015)

Anti‐IFN‐α/‐ω neutralizing antibodies from COVID‐19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity
por: Frasca, Federica, et al.
Publicado: (2022)

The paradox of NKp46(+) natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment
por: Pembroke, Tom, et al.
Publicado: (2014)

Enhancement of cytokine‐driven NK cell IFN‐γ production after vaccination of HCMV infected Africans
por: Darboe, Alansana, et al.
Publicado: (2017)

Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN‐I responses
por: Honke, Nadine, et al.
Publicado: (2015)

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells
por: Humphreys, Ian R, et al.
Publicado: (2010)

Hunting for clues: Regulatory T cells and colorectal cancer
por: Gallimore, Awen, et al.
Publicado: (2012)

Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test
por: Tomlinson, Gillian S, et al.
Publicado: (2011)

Type I IFN signaling facilitates the development of IL‐10‐producing effector CD8(+) T cells during murine influenza virus infection
por: Jiang, Li, et al.
Publicado: (2016)

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity
por: Lauder, Sarah N, et al.
Publicado: (2011)

SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10
por: Gomes, André M. C., et al.
Publicado: (2021)

High endothelial venules: Help or hindrance in the quest for antitumor immunity?
por: Gallimore, Awen, et al.
Publicado: (2013)

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN
por: Temizoz, Burcu, et al.
Publicado: (2015)

Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity
por: Simon, Anna Katharina, et al.
Publicado: (2007)

Home Sweet Home: The Tumor Microenvironment as a Haven for Regulatory T Cells
por: Ondondo, Beatrice, et al.
Publicado: (2013)

Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production
por: Flores‐Langarica, Adriana, et al.
Publicado: (2015)

Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
por: Obieglo, Katja, et al.
Publicado: (2019)

ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
por: Redpath, Stephen A, et al.
Publicado: (2013)

Suppression of tumour-specific CD4(+) T cells by regulatory T cells is associated with progression of human colorectal cancer
por: Betts, Gareth, et al.
Publicado: (2011)

Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge
por: Whibley, Natasha, et al.
Publicado: (2014)

The association of Epstein‐Barr virus infection with CXCR3(+) B‐cell development in multiple sclerosis: impact of immunotherapies
por: van Langelaar, Jamie, et al.
Publicado: (2020)

Adaptive from Innate: Human IFN-γ(+)CD4(+) T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults
por: Das, Abhishek, et al.
Publicado: (2017)

The Dual Role of High Endothelial Venules in Cancer Progression versus Immunity
por: Milutinovic, Stefan, et al.
Publicado: (2021)

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin
por: Stier, Matthew T., et al.
Publicado: (2016)

Evidence for the involvement of lung-specific γδ T cell subsets in local responses to Streptococcus pneumoniae infection
por: Kirby, Alun C, et al.
Publicado: (2007)

CD8(+) T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
por: MacHugh, Niall D, et al.
Publicado: (2009)

Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis
por: McNab, Finlay W, et al.
Publicado: (2011)

Helminth-induced CD19(+)CD23(hi) B cells modulate experimental allergic and autoimmune inflammation
por: Wilson, Mark S, et al.
Publicado: (2010)

Tuberculin status, socioeconomic differences and differences in all-cause mortality: experience from Norwegian cohorts born 1910–49
por: Liestøl, Knut, et al.
Publicado: (2009)

HIV-1 infection alters CD4(+) memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis
por: Matthews, Kerryn, et al.
Publicado: (2012)

l-Arginine deprivation impairs Leishmania major-specific T-cell responses
por: Munder, Markus, et al.
Publicado: (2009)

Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
por: Finney, Constance A M, et al.
Publicado: (2007)

IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo
por: Haeberlein, Simone, et al.
Publicado: (2010)

Leishmania donovani-induced expression of signal regulatory protein α on Kupffer cells enhances hepatic invariant NKT-cell activation
por: Beattie, Lynette, et al.
Publicado: (2010)

Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice
por: Van Roey, Griet A, et al.
Publicado: (2012)

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung
por: Redford, Paul S, et al.
Publicado: (2010)

The role of sex hormones in the development of Th2 immunity in a gender-biased model of Trichuris muris infection
por: Hepworth, Matthew R, et al.
Publicado: (2010)

Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells
por: Finney, Olivia C, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qmbc49jn7q4fgmuf0kd3enn2se