Cargando…

Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies

This perspective attempts to outline the emerging role of positron emission tomography (PET) ligand activation studies in human exercise research. By focusing on the endorphinergic system and its acclaimed role for exercise-induced antinociception and mood enhancement, we like to emphasize the uniqu...

Descripción completa

Detalles Bibliográficos
Autores principales: Boecker, Henning, Othman, Ahmed, Mueckter, Sarah, Scheef, Lukas, Pensel, Max, Daamen, Marcel, Jankowski, Jakob, Schild, HH, Tölle, Tr, Schreckenberger, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781866/
https://www.ncbi.nlm.nih.gov/pubmed/24198554
http://dx.doi.org/10.2147/OAJSM.S12054
_version_ 1782285486450016256
author Boecker, Henning
Othman, Ahmed
Mueckter, Sarah
Scheef, Lukas
Pensel, Max
Daamen, Marcel
Jankowski, Jakob
Schild, HH
Tölle, Tr
Schreckenberger, M
author_facet Boecker, Henning
Othman, Ahmed
Mueckter, Sarah
Scheef, Lukas
Pensel, Max
Daamen, Marcel
Jankowski, Jakob
Schild, HH
Tölle, Tr
Schreckenberger, M
author_sort Boecker, Henning
collection PubMed
description This perspective attempts to outline the emerging role of positron emission tomography (PET) ligand activation studies in human exercise research. By focusing on the endorphinergic system and its acclaimed role for exercise-induced antinociception and mood enhancement, we like to emphasize the unique potential of ligand PET applied to human athletes for uncovering the neurochemistry of exercise-induced psychophysiological phenomena. Compared with conventional approaches, in particular quantification of plasma beta-endorphin levels under exercise challenges, which are reviewed in this article, studying opioidergic effects directly in the central nervous system (CNS) with PET and relating opioidergic binding changes to neuropsychological assessments, provides a more refined and promising experimental strategy. Although a vast literature dating back to the 1980s of the last century has been able to reproducibly demonstrate peripheral increases of beta-endorphin levels after various exercise challenges, so far, these studies have failed to establish robust links between peripheral beta-endorphin levels and centrally mediated behavioral effects, ie, modulation of mood and/or pain perception. As the quantitative relation between endorphins in the peripheral blood and the CNS remains unknown, the question arises, to what extent conventional blood-based methods can inform researchers about central neurotransmitter effects. As previous studies using receptor blocking approaches have also revealed equivocal results regarding exercise effects on pain and mood processing, it is expected that PET and other functional neuroimaging applications in athletes may in future help uncover some of the hitherto unknown links between neurotransmission and psychophysiological effects related to physical exercise.
format Online
Article
Text
id pubmed-3781866
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-37818662013-11-06 Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies Boecker, Henning Othman, Ahmed Mueckter, Sarah Scheef, Lukas Pensel, Max Daamen, Marcel Jankowski, Jakob Schild, HH Tölle, Tr Schreckenberger, M Open Access J Sports Med Perspectives This perspective attempts to outline the emerging role of positron emission tomography (PET) ligand activation studies in human exercise research. By focusing on the endorphinergic system and its acclaimed role for exercise-induced antinociception and mood enhancement, we like to emphasize the unique potential of ligand PET applied to human athletes for uncovering the neurochemistry of exercise-induced psychophysiological phenomena. Compared with conventional approaches, in particular quantification of plasma beta-endorphin levels under exercise challenges, which are reviewed in this article, studying opioidergic effects directly in the central nervous system (CNS) with PET and relating opioidergic binding changes to neuropsychological assessments, provides a more refined and promising experimental strategy. Although a vast literature dating back to the 1980s of the last century has been able to reproducibly demonstrate peripheral increases of beta-endorphin levels after various exercise challenges, so far, these studies have failed to establish robust links between peripheral beta-endorphin levels and centrally mediated behavioral effects, ie, modulation of mood and/or pain perception. As the quantitative relation between endorphins in the peripheral blood and the CNS remains unknown, the question arises, to what extent conventional blood-based methods can inform researchers about central neurotransmitter effects. As previous studies using receptor blocking approaches have also revealed equivocal results regarding exercise effects on pain and mood processing, it is expected that PET and other functional neuroimaging applications in athletes may in future help uncover some of the hitherto unknown links between neurotransmission and psychophysiological effects related to physical exercise. Dove Medical Press 2010-09-06 /pmc/articles/PMC3781866/ /pubmed/24198554 http://dx.doi.org/10.2147/OAJSM.S12054 Text en © 2010 Boecker et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Perspectives
Boecker, Henning
Othman, Ahmed
Mueckter, Sarah
Scheef, Lukas
Pensel, Max
Daamen, Marcel
Jankowski, Jakob
Schild, HH
Tölle, Tr
Schreckenberger, M
Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title_full Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title_fullStr Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title_full_unstemmed Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title_short Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
title_sort advocating neuroimaging studies of transmitter release in human physical exercise challenges studies
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781866/
https://www.ncbi.nlm.nih.gov/pubmed/24198554
http://dx.doi.org/10.2147/OAJSM.S12054
work_keys_str_mv AT boeckerhenning advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT othmanahmed advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT muecktersarah advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT scheeflukas advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT penselmax advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT daamenmarcel advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT jankowskijakob advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT schildhh advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT tolletr advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies
AT schreckenbergerm advocatingneuroimagingstudiesoftransmitterreleaseinhumanphysicalexercisechallengesstudies