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The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781919/ https://www.ncbi.nlm.nih.gov/pubmed/24194976 http://dx.doi.org/10.1155/2013/184598 |
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author | Seo, Hyun-Ae Lee, In-Kyu |
author_facet | Seo, Hyun-Ae Lee, In-Kyu |
author_sort | Seo, Hyun-Ae |
collection | PubMed |
description | Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic. |
format | Online Article Text |
id | pubmed-3781919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37819192013-11-05 The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance Seo, Hyun-Ae Lee, In-Kyu Oxid Med Cell Longev Review Article Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic. Hindawi Publishing Corporation 2013 2013-09-08 /pmc/articles/PMC3781919/ /pubmed/24194976 http://dx.doi.org/10.1155/2013/184598 Text en Copyright © 2013 H.-A. Seo and I.-K. Lee. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Seo, Hyun-Ae Lee, In-Kyu The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title | The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title_full | The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title_fullStr | The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title_full_unstemmed | The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title_short | The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance |
title_sort | role of nrf2: adipocyte differentiation, obesity, and insulin resistance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781919/ https://www.ncbi.nlm.nih.gov/pubmed/24194976 http://dx.doi.org/10.1155/2013/184598 |
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