Cargando…

The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defe...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Hyun-Ae, Lee, In-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781919/
https://www.ncbi.nlm.nih.gov/pubmed/24194976
http://dx.doi.org/10.1155/2013/184598
_version_ 1782285499808874496
author Seo, Hyun-Ae
Lee, In-Kyu
author_facet Seo, Hyun-Ae
Lee, In-Kyu
author_sort Seo, Hyun-Ae
collection PubMed
description Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic.
format Online
Article
Text
id pubmed-3781919
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37819192013-11-05 The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance Seo, Hyun-Ae Lee, In-Kyu Oxid Med Cell Longev Review Article Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic. Hindawi Publishing Corporation 2013 2013-09-08 /pmc/articles/PMC3781919/ /pubmed/24194976 http://dx.doi.org/10.1155/2013/184598 Text en Copyright © 2013 H.-A. Seo and I.-K. Lee. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Seo, Hyun-Ae
Lee, In-Kyu
The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title_full The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title_fullStr The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title_full_unstemmed The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title_short The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
title_sort role of nrf2: adipocyte differentiation, obesity, and insulin resistance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781919/
https://www.ncbi.nlm.nih.gov/pubmed/24194976
http://dx.doi.org/10.1155/2013/184598
work_keys_str_mv AT seohyunae theroleofnrf2adipocytedifferentiationobesityandinsulinresistance
AT leeinkyu theroleofnrf2adipocytedifferentiationobesityandinsulinresistance
AT seohyunae roleofnrf2adipocytedifferentiationobesityandinsulinresistance
AT leeinkyu roleofnrf2adipocytedifferentiationobesityandinsulinresistance