Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?

The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH-MYCN mice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the inn...

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Detalles Bibliográficos
Autores principales: Carlson, Lena-Maria, Kogner, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782012/
https://www.ncbi.nlm.nih.gov/pubmed/24073359
http://dx.doi.org/10.4161/onci.24658
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author Carlson, Lena-Maria
Kogner, Per
author_facet Carlson, Lena-Maria
Kogner, Per
author_sort Carlson, Lena-Maria
collection PubMed
description The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH-MYCN mice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the innate immune system as well as immunosuppressive mediators such as transforming growth factor β (TGFβ) and thromboxane A(2). These findings pave novel avenues for the clinical management of neuroblastoma.
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spelling pubmed-37820122013-09-26 Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients? Carlson, Lena-Maria Kogner, Per Oncoimmunology Author's View The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH-MYCN mice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the innate immune system as well as immunosuppressive mediators such as transforming growth factor β (TGFβ) and thromboxane A(2). These findings pave novel avenues for the clinical management of neuroblastoma. Landes Bioscience 2013-07-01 2013-04-30 /pmc/articles/PMC3782012/ /pubmed/24073359 http://dx.doi.org/10.4161/onci.24658 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Carlson, Lena-Maria
Kogner, Per
Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title_full Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title_fullStr Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title_full_unstemmed Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title_short Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
title_sort neuroblastoma-related inflammation: may small doses of aspirin be suitable for small cancer patients?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782012/
https://www.ncbi.nlm.nih.gov/pubmed/24073359
http://dx.doi.org/10.4161/onci.24658
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