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Peptide-based anticancer vaccines: The making and unmaking of a T-cell graveyard
Poorly biodegradable, incomplete Freund’s adjuvant (IFA)-based anticancer vaccines primed CD8(+) T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunosti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782014/ https://www.ncbi.nlm.nih.gov/pubmed/24073366 http://dx.doi.org/10.4161/onci.24743 |