ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. We report here that hypomorphic Xbp1 function instruct...

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Detalles Bibliográficos
Autores principales: Niederreiter, Lukas, Fritz, Teresa M.J., Adolph, Timon E., Krismer, Anna-Maria, Offner, Felix A., Tschurtschenthaler, Markus, Flak, Magdalena B., Hosomi, Shuhei, Tomczak, Michal F., Kaneider, Nicole C., Sarcevic, Edina, Kempster, Sarah L., Raine, Tim, Esser, Daniela, Rosenstiel, Philip, Kohno, Kenji, Iwawaki, Takao, Tilg, Herbert, Blumberg, Richard S., Kaser, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782039/
https://www.ncbi.nlm.nih.gov/pubmed/24043762
http://dx.doi.org/10.1084/jem.20122341

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