Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to tumor angiogenesis. In syngeneic mouse models, i...

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Detalles Bibliográficos
Autores principales: Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S., Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782054/
https://www.ncbi.nlm.nih.gov/pubmed/24043760
http://dx.doi.org/10.1084/jem.20121571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782054/
https://www.ncbi.nlm.nih.gov/pubmed/24043760
http://dx.doi.org/10.1084/jem.20121571

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