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Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD–ALS spectrum disorders

Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of neurodegenerative processes that are observed in several neurological disorders, and in particular in most patients diagnosed with frontotemporal lobar degeneration (FTLD) or amyotrophic lateral sclerosis (ALS). A...

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Detalles Bibliográficos
Autores principales: Janssens, Jonathan, Van Broeckhoven, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782069/
https://www.ncbi.nlm.nih.gov/pubmed/23900071
http://dx.doi.org/10.1093/hmg/ddt349

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