Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment

Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signal...

Descripción completa

Detalles Bibliográficos
Autores principales: Mace, Thomas A, Bloomston, Mark, Lesinski, Gregory B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782129/
https://www.ncbi.nlm.nih.gov/pubmed/24073373
http://dx.doi.org/10.4161/onci.24891
_version_ 1782285518302609408
author Mace, Thomas A
Bloomston, Mark
Lesinski, Gregory B
author_facet Mace, Thomas A
Bloomston, Mark
Lesinski, Gregory B
author_sort Mace, Thomas A
collection PubMed
description Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.
format Online
Article
Text
id pubmed-3782129
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-37821292013-09-26 Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment Mace, Thomas A Bloomston, Mark Lesinski, Gregory B Oncoimmunology Author's View Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer. Landes Bioscience 2013-07-01 2013-05-07 /pmc/articles/PMC3782129/ /pubmed/24073373 http://dx.doi.org/10.4161/onci.24891 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Mace, Thomas A
Bloomston, Mark
Lesinski, Gregory B
Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title_full Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title_fullStr Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title_full_unstemmed Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title_short Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
title_sort pancreatic cancer-associated stellate cells: a viable target for reducing immunosuppression in the tumor microenvironment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782129/
https://www.ncbi.nlm.nih.gov/pubmed/24073373
http://dx.doi.org/10.4161/onci.24891
work_keys_str_mv AT macethomasa pancreaticcancerassociatedstellatecellsaviabletargetforreducingimmunosuppressioninthetumormicroenvironment
AT bloomstonmark pancreaticcancerassociatedstellatecellsaviabletargetforreducingimmunosuppressioninthetumormicroenvironment
AT lesinskigregoryb pancreaticcancerassociatedstellatecellsaviabletargetforreducingimmunosuppressioninthetumormicroenvironment

Ejemplares similares