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Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment

Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signal...

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Detalles Bibliográficos
Autores principales:	Mace, Thomas A, Bloomston, Mark, Lesinski, Gregory B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782129/ https://www.ncbi.nlm.nih.gov/pubmed/24073373 http://dx.doi.org/10.4161/onci.24891

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