Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the condition...

Descripción completa

Detalles Bibliográficos
Autores principales: Aarntzen, Erik HJG, Srinivas, Mangala, Schreibelt, Gerty, Heerschap, Arend, Punt, Cornelius JA, Figdor, Carl G, Oyen, Wim J, de Vries, I Jolanda M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782158/
https://www.ncbi.nlm.nih.gov/pubmed/24073362
http://dx.doi.org/10.4161/onci.24661
_version_ 1782285523619938304
author Aarntzen, Erik HJG
Srinivas, Mangala
Schreibelt, Gerty
Heerschap, Arend
Punt, Cornelius JA
Figdor, Carl G
Oyen, Wim J
de Vries, I Jolanda M
author_facet Aarntzen, Erik HJG
Srinivas, Mangala
Schreibelt, Gerty
Heerschap, Arend
Punt, Cornelius JA
Figdor, Carl G
Oyen, Wim J
de Vries, I Jolanda M
author_sort Aarntzen, Erik HJG
collection PubMed
description Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
format Online
Article
Text
id pubmed-3782158
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-37821582013-09-26 Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination Aarntzen, Erik HJG Srinivas, Mangala Schreibelt, Gerty Heerschap, Arend Punt, Cornelius JA Figdor, Carl G Oyen, Wim J de Vries, I Jolanda M Oncoimmunology Author's View Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting. Landes Bioscience 2013-07-01 2013-04-30 /pmc/articles/PMC3782158/ /pubmed/24073362 http://dx.doi.org/10.4161/onci.24661 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Aarntzen, Erik HJG
Srinivas, Mangala
Schreibelt, Gerty
Heerschap, Arend
Punt, Cornelius JA
Figdor, Carl G
Oyen, Wim J
de Vries, I Jolanda M
Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title_full Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title_fullStr Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title_full_unstemmed Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title_short Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
title_sort reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782158/
https://www.ncbi.nlm.nih.gov/pubmed/24073362
http://dx.doi.org/10.4161/onci.24661
work_keys_str_mv AT aarntzenerikhjg reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT srinivasmangala reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT schreibeltgerty reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT heerschaparend reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT puntcorneliusja reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT figdorcarlg reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT oyenwimj reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination
AT devriesijolandam reducingcellnumberimprovesthehomingofdendriticcellstolymphnodesuponintradermalvaccination

Ejemplares similares