Development of interferon γ-based immunocytokines targeting renal cancer

Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. These immunocytokines efficiently labeled renal cancer cells, and, when combi...

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Detalles Bibliográficos
Autores principales: Chen, Peirong, Balachandran, Siddharth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782162/
https://www.ncbi.nlm.nih.gov/pubmed/24073376
http://dx.doi.org/10.4161/onci.24964
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author Chen, Peirong
Balachandran, Siddharth
author_facet Chen, Peirong
Balachandran, Siddharth
author_sort Chen, Peirong
collection PubMed
description Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. These immunocytokines efficiently labeled renal cancer cells, and, when combined with the proteasome inhibitor bortezomib, killed them by activating a RIP1-dependent necrotic pathway.
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spelling pubmed-37821622013-09-26 Development of interferon γ-based immunocytokines targeting renal cancer Chen, Peirong Balachandran, Siddharth Oncoimmunology Author's View Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. These immunocytokines efficiently labeled renal cancer cells, and, when combined with the proteasome inhibitor bortezomib, killed them by activating a RIP1-dependent necrotic pathway. Landes Bioscience 2013-07-01 2013-05-16 /pmc/articles/PMC3782162/ /pubmed/24073376 http://dx.doi.org/10.4161/onci.24964 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chen, Peirong
Balachandran, Siddharth
Development of interferon γ-based immunocytokines targeting renal cancer
title Development of interferon γ-based immunocytokines targeting renal cancer
title_full Development of interferon γ-based immunocytokines targeting renal cancer
title_fullStr Development of interferon γ-based immunocytokines targeting renal cancer
title_full_unstemmed Development of interferon γ-based immunocytokines targeting renal cancer
title_short Development of interferon γ-based immunocytokines targeting renal cancer
title_sort development of interferon γ-based immunocytokines targeting renal cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782162/
https://www.ncbi.nlm.nih.gov/pubmed/24073376
http://dx.doi.org/10.4161/onci.24964
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AT balachandransiddharth developmentofinterferongbasedimmunocytokinestargetingrenalcancer

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