B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities

A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosupp...

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Detalles Bibliográficos
Autores principales: Jeon, Hyungjun, Ohaegbulam, Kim C, Abadi, Yael M, Zang, Xingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782163/
https://www.ncbi.nlm.nih.gov/pubmed/24073367
http://dx.doi.org/10.4161/onci.24744
Descripción
Sumario:A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

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