B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities

A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosupp...

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Autores principales: Jeon, Hyungjun, Ohaegbulam, Kim C, Abadi, Yael M, Zang, Xingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782163/
https://www.ncbi.nlm.nih.gov/pubmed/24073367
http://dx.doi.org/10.4161/onci.24744
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author Jeon, Hyungjun
Ohaegbulam, Kim C
Abadi, Yael M
Zang, Xingxing
author_facet Jeon, Hyungjun
Ohaegbulam, Kim C
Abadi, Yael M
Zang, Xingxing
author_sort Jeon, Hyungjun
collection PubMed
description A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.
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spelling pubmed-37821632013-09-26 B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities Jeon, Hyungjun Ohaegbulam, Kim C Abadi, Yael M Zang, Xingxing Oncoimmunology Author's View A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth. Landes Bioscience 2013-07-01 2013-04-30 /pmc/articles/PMC3782163/ /pubmed/24073367 http://dx.doi.org/10.4161/onci.24744 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Jeon, Hyungjun
Ohaegbulam, Kim C
Abadi, Yael M
Zang, Xingxing
B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title_full B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title_fullStr B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title_full_unstemmed B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title_short B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
title_sort b7x and myeloid-derived suppressor cells in the tumor microenvironment: a tale of two cities
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782163/
https://www.ncbi.nlm.nih.gov/pubmed/24073367
http://dx.doi.org/10.4161/onci.24744
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